The US rapper was hospitalised earlier this week with exhaustion and the 'Lonely' hitmaker insists he "wouldn't deny" that the star's plight could have something to do with him being married to one of the family's females, Kim Kardashian West, insisting "all evidence points to it".
When asked if he thinks Kanye's situation might have anything to do with a "Kardashian curse", he said: "I actually thought about that, because at first it was a big joke to everybody.
"But in Africa there have always been sayings that sometimes you can't deny what you see, but oftentimes the eye may deceive you too.
"It's hard to comment on something like that as much as the evidence may show you that that's possible, you don't wanna discredit it as it may just be bad luck.
"I just wanna investigate this further just for fun, it is something to think about though. I wouldn't deny it but I wouldn't promote it either.
Akon is now on the lookout to see if anything bad happens to Kim's half-sister Kylie Jenner's boyfriend Tyga.
He added to TMZ: "If something mental happens with Tyga then we can say it's safe to say as that's three in a row."
There have long been rumours of a so-called "Kardashian curse" after some of the guys associated with the family's females fell on hard times.
Khloe Kardashian's ex-husband Lamar Odom collapsed and almost died at a Nevada brothel last year after a drugs and alcohol binge.
And last November, Kourtney Kardashian's former partner Scott Disick - who she has kids Mason, six, Penelope, four, and 23-month-old Reign with - spent a month in Cliffside Malibu rehab centre to get treatment with alcohol and other substance abuse issues.