Ghana coach Avram Grant has been forced to leave injured stars Jeffrey Schlupp and Majeed Waris out of his final squad for the 2015 Africa Cup of Nations.
Leicester City's Schlupp will be out for three weeks, according to Ghana's Football Association.
Waris is replaced in the 23-man line-up by Norway-based striker Mahatma Otoo.
Defender Samuel Inkoom is amongst those dropped from the party for the tournament in Equatorial Guinea, which starts on 17 January.
Cambridge United's Kwesi Appiah has been included in the party, after scoring for the Black Stars in a warm up game in Portugal on Wednesday.
He will be making his Nations Cup debut, along with Baba Rahman, Daniel Amartey, Frank Acheampong and David Accam.
Schlupp and Waris had been serious injury doubts but were included in Grant's provisional party on the hope that they would recover.
Striker Asamoah Gyan leads the squad once again and will shoulder much of the goal scoring responsibilities.
Goalkeepers: Razak Braimah (Mirandes, Spain), Fatau Dauda (AshGold) and Ernest Sowah (Don Bosco, DR Congo)
Defenders: Harrison Afful (Esperance, Tunisia), John Boye (Erciyesspor, Turkey), Jonathan Mensah (Evian, France), Awal Mohammed (Maritzburg, South Africa), Baba Rahman (Augsburg, Germany), Gyimah Edwin (Mpumalanga Black Aces, South Africa), Daniel Amartey, (FC Copenhagen, Denmark)
Midfielders: Rabiu Mohammed (Krasnodar, Russia), Emmanuel Agyemang-Badu (Udinese, Italy), Afriyie Acquah (Parma, Italy), Solomon Asante (T.P. Mazembe, DR Congo), Christian Atsu (Everton, England), Mubarak Wakaso (Celtic, Scotland), Andre Ayew (Olympique Marseille, France), Frank Acheampong (Anderlecht, Belgium), David Accam (Chicago Fire, USA)
Strikers: Jordan Ayew (Lorient, France), Mahatma Otoo (Songdal, Norway) Asamoah Gyan (Al Ain, UAE), Kwesi Appiah (Cambridge United, England)